Morphology of nares associated with stereo-olfaction in baleen whales.

The sensory mechanisms used by baleen whales (Mysticeti) for locating ephemeral, dense prey patches in vast marine habitats are poorly understood. Baleen whales have a functional olfactory system with paired rather than single blowholes (nares), potentially enabling stereo-olfaction. Dimethyl sulfide (DMS) is an odorous gas emitted by phytoplankton in response to grazing by zooplankton. Some seabirds use DMS to locate prey, but this ability has not been demonstrated in whales. For 14 extant species of baleen whale, nares morphometrics (imagery from unoccupied aerial systems, UAS) was related to published trophic level indices using Bayesian phylogenetic mixed modelling. A significant negative relationship was found between nares width and whale trophic level (ß = -0.08, lower 95% CI = -0.13, upper 95% CI = -0.03), corresponding with a 39% increase in nares width from highest to lowest trophic level. Thus, species with nasal morphology best suited to stereo-olfaction are more zooplanktivorous. These findings provide evidence that some baleen whale species may be able to localize odorants e.g. DMS. Our results help direct future behavioural trials of olfaction in baleen whales, by highlighting the most appropriate species to study. This is a research priority, given the potential for DMS-mediated plastic ingestion by whales.

Dynamic Grammar Pruning for Program Size Reduction in Symbolic Regression.

Grammar is a key input in grammar-based genetic programming. Grammar design not only influences performance, but also program size. However, grammar design and the choice of productions often require expert input as no automatic approach exists. This research work discusses our approach to automatically reduce a bloated grammar. By utilizing a simple Production Ranking mechanism, we identify productions which are less useful and dynamically prune those to channel evolutionary search towards better (smaller) solutions. Our objective in this work was program size reduction without compromising generalization performance. We tested our approach on 13 standard symbolic regression datasets with Grammatical Evolution. Using a grammar embodying a well-defined function set as a baseline, we compare effective genome length and test performance with our approach. Dynamic grammar pruning achieved significantly better genome lengths for all datasets, while significantly improving generalization performance on three datasets, although it worsened in five datasets. When we utilized linear scaling during the production ranking stages (the first 20 generations) the results dramatically improved. Not only were the programs smaller in all datasets, but generalization scores were also significantly better than the baseline in 6 out of 13 datasets, and comparable in the rest. When the baseline was also linearly scaled as well, the program size was still smaller with the Production Ranking approach, while generalization scores dropped in only three datasets without any significant compromise in the rest.

Assembling Phenothiazine into a Porous Coordination Cage to Improve Its Photocatalytic Efficiency for Organic Transformations.

Photo-catalysis by small-molecules is often limited by catalyst degradation and low electron-transfer efficiency. Herein we report a stable N-phenyl-phenothiazine (PTH)-derived porous coordination cage (PCC) as a highly efficient photocatalyst. By the incorporation of the photocatalytic PTH moiety into a PCC, aggregation-induced quenching (AIQ) was shown to be reduced. An improvement in catalyst stability was discovered, ascribed to the synergistic effects of the PTH moieties. The catalyst, operating through a photolytic single-electron transfer, was utilized for photo-catalyzed dehalogenation and borylation. Evaluation of the catalytic mechanism in the borylation reaction showed that the improved performance results from the more efficient formation of the electron donor-acceptor (EDA) complex with the cage. This discovery provides a potential strategy to improve the photophysical properties and stabilities of small-molecule organic photocatalysts via supramolecular chemistry.

Fuzzy Pattern Tree Evolution Using Grammatical Evolution.

A novel approach to induce Fuzzy Pattern Trees using Grammatical Evolution is presented in this paper. This new method, called Fuzzy Grammatical Evolution, is applied to a set of benchmark classification problems. Experimental results show that Fuzzy Grammatical Evolution attains similar and oftentimes better results when compared with state-of-the-art Fuzzy Pattern Tree composing methods, namely Fuzzy Pattern Trees evolved using Cartesian Genetic Programming, on a set of benchmark problems. We show that, although Cartesian Genetic Programming produces smaller trees, Fuzzy Grammatical Evolution produces better performing trees. Fuzzy Grammatical Evolution also benefits from a reduction in the number of necessary user-selectable parameters, while Cartesian Genetic Programming requires the selection of three crucial graph parameters before each experiment. To address the issue of bloat, an additional version of Fuzzy Grammatical Evolution using parsimony pressure was tested. The experimental results show that Fuzzy Grammatical Evolution with this extension routinely finds smaller trees than those using Cartesian Genetic Programming without any compromise in performance. To improve the performance of Fuzzy Grammatical Evolution, various ensemble methods were investigated. Boosting was seen to find the best individuals on half the benchmarks investigated.

Design of a cryptographically secure pseudo random number generator with grammatical evolution.

This work investigates the potential for using Grammatical Evolution (GE) to generate an initial seed for the construction of a pseudo-random number generator (PRNG) and cryptographically secure (CS) PRNG. We demonstrate the suitability of GE as an entropy source and show that the initial seeds exhibit an average entropy value of 7.940560934 for 8-bit entropy, which is close to the ideal value of 8. We then construct two random number generators, GE-PRNG and GE-CSPRNG, both of which employ these initial seeds. We use Monte Carlo simulations to establish the efficacy of the GE-PRNG using an experimental setup designed to estimate the value for pi, in which 100,000,000 random numbers were generated by our system. This returned the value of pi of 3.146564000, which is precise up to six decimal digits for the actual value of pi. We propose a new approach called control_flow_incrementor to generate cryptographically secure random numbers. The random numbers generated with CSPRNG meet the prescribed National Institute of Standards and Technology SP800-22 and the Diehard statistical test requirements. We also present a computational performance analysis of GE-CSPRNG demonstrating its potential to be used in industrial applications.

Grammatical Evolution of Complex Digital Circuits in SystemVerilog.

The evolution of complex circuits remains a challenge for the Evolvable Hardware field in spite much effort. There are two major issues: the amount of testing required and the low evolvability of representation structures to handle complex circuitry, at least partially due to the destructive effects of genetic operators. A 64-bit × 64-bit add-shift multiplier circuit modelled at register-transfer level in SystemVerilog would require approximately 33,200 gates when synthesized using Yosys Open SYnthesis Suite tool. This enormous gate count makes evolving such a circuit at the gate-level difficult. We use Grammatical Evolution (GE) and SystemVerilog, a hardware description language (HDL), to evolve fully functional parameterized Adder, Multiplier, Selective Parity and Up-Down Counter circuits at a more abstract level other than gate level-register transfer level. Parameterized modules have the additional benefit of not requiring a re-run of evolutionary experiments if multiple instances with different input sizes are required. For example, a 64-bit × 64-bit and 128-bit × 128-bit multipliers etc., can be instantiated from  a fully evolved functional and parameterized N-bit × N-bit multiplier. The Adder (6.4 × ), Multiplier (10.7 × ) and Selective Parity (6.7 × ) circuits are substantially larger than the current state of the art for evolutionary approaches. We are able to scale so dramatically because of the use of a HDL, which permits us to operate at a register-transfer level. Furthermore, we adopt a well known technique for reducing testing from digital circuit design known as corner case testing. Skilled circuit designers rely on this to avoid time-consuming exhaustive testing. We demonstrate a simple way to identify and use corner cases for evolutionary testing and show that it enables the generation of massively complex circuits. All circuits were successfully evolved without resorting to the use of any standard decomposition methods, due to our ability to use programming constructs and operators available in SystemVerilog.

Instantaneous microwave-photonic spatial-spectral channelization via k-space imaging.

The ability to both spatially and spectrally demultiplex wireless transmitters enables communication networks with higher spectral and energy efficiency. In practice, demultiplexing requires sub-millisecond latency to map the dynamics of the user space in real-time. Here, we present a system architecture, referred to as k-space imaging, which channelizes the radio frequency signals both spatially and spectrally through optical beamforming, where the latency is limited only by the speed of light traversing the optical components of the receiver. In this architecture, a phased antenna array samples radio signals, which are then coupled into electro-optic modulators (EOM) that coherently up-convert these signals to the optical domain, preserving their relative phases. The received signals, now optical sidebands, are transmitted in optical fibers of varying path lengths, which act as true time delays that yield frequency-dependent optical phases. The output facets of the optical fibers form a two-dimensional optical phased array in an arrangement preserving the phases generated by the angle of arrival (AoA) and the time-delay phases. Directing the beams emanating from the fibers through an optical lens produces a two-dimensional Fourier transform of the optical field at the fiber array. Accordingly, the optical beam formed at the back focal plane of the lens is steered based upon the phases, providing the angle of arrival and instantaneous frequency measurement (IFM), with latency determined by the speed of light over the optical path length. We present a numerical evaluation and experimental demonstration of this passive AoA- and frequency-detection capability.

Quantitative analysis of myokymic discharges in radiation versus nonradiation cases.

INTRODUCTION: Myokymic discharges are classically associated with nerve injury from prior radiation but may occur in other neuromuscular disorders. Using quantitative analysis we aimed to identify the spectrum of conditions in which myokymic discharges are present and determine if there are electrophysiological features that distinguish postradiation from nonradiation causes of myokymia. METHODS: We reviewed the clinical history of all patients examined in our electromyography labs with myokymic discharges recorded from June 2017 to February 2020. Quantitative analysis of each myokymic discharge was performed using a custom MATLAB script, assessing features such as burst frequency, spikes per burst, and burst regularity. RESULTS: Eighty-eight distinct myokymic discharges (70 patients) were analyzed: 51 postradiation recordings from 35 patients and 37 recordings from 35 nonradiation patients. The diagnostic spectrum of nonradiation cases was diverse, with common causes being median neuropathy (n = 8), cervical (n = 7), and lumbar (n = 5) radiculopathy, and motor neuron disease (n = 5). On quantitative analysis, postradiation myokymia had an increased burst-to-silence ratio (median, 0.29; nonradiation, 0.08) and greater peak number (median, 15; nonradiation, 7). Except for one patient with hereditary peripheral nerve hyperexcitability, all patients who had two or more muscles demonstrating myokymic discharges belonged to postradiation group. CONCLUSIONS: Myokymic discharges can be seen in diverse neuromuscular conditions; most common in our cohort was chronic median neuropathy. Postradiation myokymia appears to have distinguishing morphological features when quantitatively analyzed compared with nonradiation cases.

Experimental and theoretical inquiry into optical properties of graphene derivatives.

Graphene oxide (GO), a functional derivative of graphene, is a promising nanomaterial for a variety of optoelectronic applications as it exhibits fluorescence and maintains many of graphene's beneficial physical properties. although other graphene derivatives are chemically plausible and may serve to the benefit of the aforementioned applications, GO remains the one heavily used. the nature of optical behavior of other graphene derivatives has yet to be fully understood and studied. in this work we develop a variety of graphene derivatives and characterize their optical properties concomitantly suggesting a unified model for optical emission in graphene derivatives. in this process we examine the influence of different functional groups on the surface of graphene on its optoelectronic properties. mildly oxidized graphene (oxo-g1), nitrated graphene, arylated graphene, brominated graphene, and fluorinated graphene are obtained and characterized via TEM and EDX, FTIR and fluorescence spectroscopies with the latter indicating a potential band gap-derived fluorescence from each of the materials. this suggests that optical properties of graphene derivatives have minimal functional group dependence and are manifested by the localized environments within the flakes. this is confirmed by the hyperchem theoretical modeling of all aforementioned graphene derivatives indicating a similar electronic configuration for all, assessed by the pm3 semi-empirical approach. this work can further serve to describe and predict optical properties of similar graphene-based structures and promote graphene derivatives other than GO for utilization in research and industry.

Electric field quenching of graphene oxide photoluminescence.

With the advent of graphene, there has been an interest in utilizing this material and its derivative, graphene oxide (GO) for novel applications in nanodevices such as bio and gas sensors, solid-state supercapacitors and solar cells. Although GO exhibits lower conductivity and structural stability, it possesses an energy band gap that enables fluorescence emission in the visible/near infrared leading to a plethora of optoelectronic applications. In order to allow fine-tuning of its optical properties in the device geometry, new physical techniques are required that, unlike existing chemical approaches, yield substantial alteration of GO structure. Such a desired new technique is one that is electronically controlled and leads to reversible changes in GO optoelectronic properties. In this work, we for the first time investigate the methods to controllably alter the optical response of GO with the electric field and provide theoretical modeling of the electric field-induced changes. Field-dependent GO emission is studied in bulk GO/polyvinylpyrrolidone films with up to 6% reversible decrease under 1.6 V µm-1 electric fields. On an individual flake level, a more substantial over 50% quenching is achieved for select GO flakes in a polymeric matrix between interdigitated microelectrodes subject to two orders of magnitude higher fields. This effect is modeled on a single exciton level by utilizing Wentzel, Kremer, and Brillouin approximation for electron escape from the exciton potential well. In an aqueous suspension at low fields, GO flakes exhibit electrophoretic migration, indicating a degree of charge separation and a possibility of manipulating GO materials on a single-flake level to assemble electric field-controlled microelectronics. As a result of this work, we suggest the potential of varying the optical and electronic properties of GO via the electric field for the advancement and control over its optoelectronic device applications.

Iron Deficiency and Its Role in Sleep Disruption in Patients With Angelman Syndrome.

OBJECTIVE: To determine if Angelman syndrome patients with sleep complaints have an increased risk of iron deficiency, and if iron therapy improves their sleep difficulties. BACKGROUND: About two-thirds of Angelman syndrome patients experience sleep difficulties, which are likely multifactorial. Because iron deficiency can contribute toward restlessness in sleep, we investigated whether it might be a contributing factor in this special population. METHODS: This retrospective study involved medical record review of Angelman syndrome patients <18 years old who had attended our multidisciplinary Angelman syndrome clinic and had sleep complaints. Serum ferritin levels were compared to age- and sex-matched controls. Sleep history and nocturnal polysomnogram findings of the Angelman syndrome patients were also characterized. RESULTS: Nineteen Angelman syndrome patients (9 female, mean age 6.2±4.4 years) were identified. All 19 reported sleep difficulties. The mean serum ferritin level was 19.9±8.5 µg/L, while that in controls was 27.8±17.8 µg/L (P value .13). The odds ratio of iron deficiency in Angelman syndrome compared to controls was 4.17 (95% confidence interval 1.23-14.10), using normal serum ferritin level of 24 µg/L based on literature. Fifteen Angelman syndrome patients underwent nocturnal polysomnogram with 9/15 showing an elevated periodic limb movement index (overall mean 9.8±10.4). Seventeen of 19 received iron therapy. Twelve had follow-up after iron therapy, with parents reporting improved sleep quality. Eight had serum ferritin levels rechecked after iron therapy, showing a mean increase of 24±5.1 µg/L. CONCLUSIONS: Sleep difficulties in Angelman syndrome, though multifactorial, may in part be related to iron deficiency. Treatment with iron improved sleep to a modest degree in this population.

Long-term incidence of glioma in Olmsted County, Minnesota, and disparities in postglioma survival rate: a population-based study.

BACKGROUND: We assessed glioma incidence and disparities in postglioma survival rate in the Olmsted County, Minnesota, population. METHODS: This population-based study assessed the incidence of pathologically confirmed primary gliomas between January 1, 1995, and December 31, 2014. Age- and sex-adjusted incidence rates per 100 000 person-years were calculated and standardized to the US white 2010 population. We compared incidence trends of glioma during our study period with previously published Olmsted County data from 1950 to 1990. We assessed postglioma survival rates among individuals with different socioeconomic status (SES), which was measured by a validated individual HOUsing-based SES index (HOUSES). RESULTS: We identified 135 incident glioma cases (93% white) with 20 pediatric (50% female) and 115 adult cases (44% female). Overall incidence rate during our study period, 5.51 per 100 000 person-years (95% CI: 4.56-6.46), showed no significant changes and was similar to that seen in 1950 to 1990, 5.5 per 100 000 person-years. The incidence of pediatric (age < 20 years) glioma was 2.49 (95% CI: 1.40-3.58), whereas adult glioma incidence was 6.47 (95% CI: 5.26-7.67). Among those with grade II to IV gliomas, individuals with lower SES (< median HOUSES) had significantly lower 5-year survival rates compared to those with higher SES, adjusted hazard ratio 1.61 (95% CI: 1.01-2.85). CONCLUSION: In a well-defined North American population, long-term glioma incidence appears stable since 1950. Significant socioeconomic disparities exist for postglioma survival.

Log-periodic temporal apertures for grating lobe suppression in k-space tomography.

Millimeter-wave (mmW) imaging receivers have demonstrated the ability to sense radio-frequency (RF) waves using traditional phased antenna array techniques, and, through a coherent photonic up-conversion process, image these waves using free-space optical systems. Building upon the idea of coherent up-conversion, k-space tomography extends the functionality of the millimeter-wave imaging receiver as a two-dimensional spatial processing unit to three-dimensional sensing with the addition of frequency detection. In this configuration, an arrayed waveguide grating, or temporal aperture, is implemented following the photonic up-conversion of RF signals received by the phased array. These waveguides of varying length add a spectral beam-forming network to the existing spatial beam-forming of the mmW-imaging receiver. The introduction of three-dimensional phase information to the imaging system disrupts the ability to directly image the RF signal distribution on a photo-detector array, requiring the application of tomographic algorithms to reconstruct the power distribution of the received signals. In order to receive and properly recover the spatial-spectral distribution of RF sources, the antenna array and temporal array must be sampled adequately to avoid introduction of grating artifacts into the system response. Grating lobes, an artifact of regular spacing of elements within a grating, restrict the alias-free field of regard for antenna arrays, or the free spectral range for time-delay based arrays, thus limiting the spatial-spectral monitoring of RF sources via the k-space imaging modality. To alleviate this constraint, we present a non-uniform log-periodic array sampling for the k-space tomographic time-delay based aperture, greatly increasing the free spectral range of the system while maintaining the number of existing channels.

Establishing Normal Values for F-Wave Latencies in Diagnosing Peripheral Neuropathies for the Pediatric Population.

PURPOSE: We present a unique technique applying F-wave latencies to assist in the diagnosis of peripheral neuropathy within the pediatric age group. METHODS: We calculated an F-wave estimated deviance adjusted for limb length measurements, distal motor conduction velocity, and distal motor latencies. We compared the F-wave estimated deviance from the normal subjects with those with peripheral neuropathy (both axonal and demyelinating) to establish diagnostic accuracy in pediatric patients. RESULTS: The normal range for the F-wave estimated deviance in the upper limb was -1 to +6 ms and in the lower limb was -8 to +5 ms. When compared with 82 subjects with peripheral neuropathy, there was a significant difference between the normal subjects and those with neuropathy (P values between 0.002 and 0.0005 for each of the individual nerves tested). CONCLUSIONS: The F-wave estimated deviance is independent of age and can be accurately applied to the electrodiagnostic testing of pediatric patients with suspected neuropathy.

Variation of Optical Properties of Nitrogen-doped Graphene Quantum Dots with Short/Mid/Long-wave Ultraviolet for the Development of the UV Photodetector.

Nitrogen-doped graphene quantum dots (NGQDs) synthesized from a single glucosamine precursor are utilized to develop a novel UV photodetector. Optical properties of NGQDs can be altered with short- (254 nm), mid- (302 nm), and long-wave (365 nm) ultraviolet (UV) exposure leading to the reduction of absorption from deep to mid UV (200-320 nm) and enhancement above 320 nm. Significant quenching of blue and near-IR fluorescence accompanied by the dramatic increase of green/yellow emission of UV-treated NGQDs can be used as a potential UV-sensing mechanism. These emission changes are attributed to the reduction of functional groups detected by Fourier transformed infrared spectroscopy and free-radical-driven polymerization of the NGQDs increasing their average size from 4.70 to 11.20 nm at 60 min treatment. Due to strong UV absorption and sensitivity to UV irradiation, NGQDs developed in this work are utilized to fabricate UV photodetectors. Tested under long-/mid-/short-wave UV, these devices show high photoresponsivity (up to 0.59 A/W) and excellent photodetectivity (up to 1.03 × 1011 Jones) with highly characteristic wavelength-dependent reproducible response. This study suggests that the optical/structural properties of NGQDs can be controllably altered via different wavelength UV treatment leading us to fabricate NGQD-based novel UV photodetectors providing high responsivity and detectivity.

Asthma and risk of glioma: a population-based case-control study.

OBJECTIVES: Literature suggests an inconsistent, but largely inverse, association between asthma and risk of glioma, which is primarily due to methodological inconsistency in sampling frame and ascertainment of asthma. The objective of the study was to clarify the association between asthma and risk of glioma by minimising methodological biases (eg, recall and detection bias). DESIGN: A population-based case-control study. SETTING: General population in Olmsted County, Minnesota, USA. PARTICIPANTS: All eligible biopsy-proven incident glioma cases (1995-2014) and two sets of controls among residents matched to age and sex (first set: community controls without glioma; second set: MRI-negative controls from the same community). METHODS: The predetermined asthma criteria via medical record review were applied to ascertain asthma status of cases and controls. History of asthma prior to index date was compared between glioma cases and their matched controls using conditional logistic regression models. Propensity score for asthma status was adjusted for multivariate analysis. RESULTS: We enrolled 135 glioma cases (median age at index date: 53 years) and 270 controls. Of the cases, 21 had a history of asthma (16%), compared with 36 of MRI controls (27%) (OR (95% CI) 0.48 (0.26 to 0.91), p=0.03). With MRI controls, an inverse association between asthma and risk of glioma persisted after adjusting for the propensity score for asthma status, but did not reach statistical significance probably due to the lack of statistical power (OR (95% CI) 0.48 (0.21 to 1.09); p=0.08). Based on comparison of characteristics of controls and cases, community controls seem to be more susceptible to a detection bias. CONCLUSIONS: While differential detection might account for the association between asthma and risk of glioma, asthma may potentially pose a protective effect on risk of glioma. Our study results need to be replicated by a larger study.

Nerve conduction normal values for electrodiagnosis in pediatric patients.

INTRODUCTION: Existing normal value references for pediatric nerve conduction studies (NCS) are based on limited sample sizes with uncertain reliability, suggesting a need for better normative data. METHODS: Electronic medical records were reviewed for pediatric patients (0 to <18 years) with normal findings on electromyography and NCS during the period from January 1, 1997 through September 20, 2017. Electrodiagnostic and demographic data were collected. Gaussian and descriptive statistics were used to establish normal values by age group. RESULTS: In this study we analyzed 1,918 normal NCS on 1,849 unique pediatric patients. Patients were stratified by age: 0 to <1 month; 1 to <6 months; 6 to <12 months; 12 to <24 months; 2 to <3 years; 3 to <4 years; 4 to <5 years; 5 to <10 years; 10 to <15 years; and 15 to <18 years. Normal reference ranges for amplitude, conduction velocity, and distal latency were established for each age group for 4 motor and 4 sensory nerves. DISCUSSION: The large sample size of this study provides reliable reference values for interpreting pediatric NCS. Muscle Nerve 60: 155-160, 2019.

Fin whale (Balaenoptera physalus) mitogenomics: A cautionary tale of defining sub-species from mitochondrial sequence monophyly.

The advent of massive parallel sequencing technologies has resulted in an increase of studies based upon complete mitochondrial genome DNA sequences that revisit the taxonomic status within and among species. Spatially distinct monophyly in such mitogenomic genealogies, i.e., the sharing of a recent common ancestor among con-specific samples collected in the same region has been viewed as evidence for subspecies. Several recent studies in cetaceans have employed this criterion to suggest subsequent intraspecific taxonomic revisions. We reason that employing intra-specific, spatially distinct monophyly at non-recombining, clonally inherited genomes is an unsatisfactory criterion for defining subspecies based upon theoretical (genetic drift) and practical (sampling effort) arguments. This point was illustrated by a re-analysis of a global mitogenomic assessment of fin whales, Balaenoptera physalus spp., published by Archer et al. (2013), which proposed to further subdivide the Northern Hemisphere fin whale subspecies, B. p. physalus. The proposed revision was based upon the detection of spatially distinct monophyly among North Atlantic and North Pacific fin whales in a genealogy based upon complete mitochondrial genome DNA sequences. The extended analysis conducted in this study (1676 mitochondrial control region, 162 complete mitochondrial genome DNA sequences and 20 microsatellite loci genotyped in 380 samples) revealed that the apparent monophyly among North Atlantic fin whales reported by Archer et al. (2013) to be due to low sample sizes. In conclusion, defining sub-species from monophyly (i.e., the absence of para- or polyphyly) can lead to erroneous conclusions due to relatively "trivial" aspects, such as sampling. Basic population genetic processes (i.e., genetic drift and migration) also affect the time to the most recent common ancestor and hence the probability that individuals in a sample are monophyletic.